South Bend is a city on the St. Joseph river. It is the fourth largest city in Indiana and county seat of St. Joseph County. It is the economic and cultural hub of the region commonly known as Michiana, and may be best known as the home of the University of Notre Dame. South Bend lies along the Indiana Toll Road at the south-most turn in the St. Joseph River, from which it derives its name. Today, the largest industries in South Bend are health care, education, and small business. A large tourism sector also exists, mainly supported by the University of Notre Dame.